人才隊伍
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劉海鷹
個人簡介
中國醫學科學院/北京協和醫學院病原生物學研究所黨委副書記、紀委書記、課題組組長。全國結核病防治綜合質量控制專家指導委員會委員、中國免疫學會感染免疫分會委員、中國防癆協會結核病基礎專業分會常委。《中華結核和呼吸雜志》和《結核與肺部疾病雜志》編委。
主要研究方向是感染、炎癥與免疫機制研究。主持或參與國家科技重大專項、國家重點研發計劃、國家自然科學基金、醫學與健康科技創新工程等多項國家級和院校級科研項目，參與多項戰略咨詢項目研究。在SCI收錄雜志上發表學術論文30余篇；獲得6項發明專利授權；獲得中華醫學科學技術獎二等獎（排名第五）、重大專項創新團隊獎。
研究方向
結核病等我國重大傳染病免疫機制及新型生物標識的研究。
科研項目
1. 國家重點研發計劃（2021-2026），結核病新型診斷、治療、干預手段及產品研發，課題骨干。
2. 中國醫學科學院中央級公益性科研院所基本科研業務費（2020-2022），西藏自治區結核病流行菌株特征及致病特點研究，課題負責人。
3. 國家自然科學基金委員會面上項目（2021-2024），血管生成素2參與活動性肺結核免疫機制研究，課題負責人。
4. 中國工程院咨詢研究項目(2019-2020 )，中國與法國等發達國家結核病防治體系的對比研究，課題骨干。
5. 國家外專局高端外國專家項目(2018-1019)，結核病新型分子標識研究，課題負責人。
6. 國家科技重大專項 (2017-2020)，菌陰結核病和結核分枝桿菌潛伏感染相關生物標志物研究，子課題負責人。
7. 中國醫學科學院醫學與健康科技創新工程項目(2016-2021)，感染性疾病（結核病等）診治新策略研究，課題骨干。
8. 國家自然科學基金委員會面上項目(2012-2015)，接頭蛋白Gab2調控結核病發生、發展的免疫學功能研究，課題負責人。
9. 國家科技重大專項 (2012-2015)，結核病分子標識的研究，課題負責人。
10. 國家科技重大專項(2008-2010)，結核病免疫保護機制研究，課題負責人。
11. 國家科技重大專項 (2008-2010)，結核病診斷分子標識研究，子課題負責人。
研究成果
1. Dong, H., Y. Zhang, Y. Zou, Y. Chen, J. Yue, H. Liu and X. Jiang (2021). "Elevated chemokines concentration is associated with disease activity in Takayasu arteritis." Cytokine 143: 155515.
2. Li, H., L. Liu, W. J. Zhang, X. Zhang, J. Zheng, L. Li, X. Zhu, Q. Yang, M. Zhang, H. Liu, X. Chen and Q. Jin (2019). "Analysis of the Antigenic Properties of Membrane Proteins of Mycobacterium tuberculosis." Sci Rep 9(1): 3042.
3. Liu, C. H., H. Liu and B. Ge (2017). "Innate immunity in tuberculosis: host defense vs pathogen evasion." Cell Mol Immunol 14(12): 963-975.
4. Hu, Y., Y. Zhang, X. Ren, Y. Liu, Y. Xiao, L. Li, F. Yang, H. Su, F. Liu, H. Liu, B. Cao and Q. Jin (2016). "A case report demonstrating the utility of next generation sequencing in analyzing serial samples from the lung following an infection with influenza A (H7N9) virus." J Clin Virol 76: 45-50.
5. Yu, Y., D. Jin, S. Hu, Y. Zhang, X. Zheng, J. Zheng, M. Liao, X. Chen, M. Graner, H. Liu and Q. Jin (2015). "A novel tuberculosis antigen identified from human tuberculosis granulomas." Mol Cell Proteomics 14(4): 1093-1103.
6. Zhang, M., G. Zeng, Q. Yang, J. Zhang, X. Zhu, Q. Chen, P. Suthakaran, Y. Zhang, Q. Deng, H. Liu, B. Zhou and X. Chen (2014). "Anti-tuberculosis treatment enhances the production of IL-22 through reducing the frequencies of regulatory B cell." Tuberculosis (Edinb) 94(3): 238-244.
7. Liu, L., W. J. Zhang, J. Zheng, H. Fu, Q. Chen, Z. Zhang, X. Chen, B. Zhou, L. Feng, H. Liu and Q. Jin (2014). "Exploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis." Mol Cell Proteomics 13(3): 897-906.
8. Hu, S., Y. Zhang, Y. Yu, D. Jin, X. Zhang, S. Gu, H. Jia, X. Chen, Z. Zhang, Q. Jin, Y. Ke and H. Liu (2014). "Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis." Am J Respir Cell Mol Biol 51(4): 575-585.
9. Zhang, Y., H. Liu, L. Wang, F. Yang, Y. Hu, X. Ren, G. Li, Y. Yang, S. Sun, Y. Li, X. Chen, X. Li and Q. Jin (2013). "Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease." PLoS One 8(6): e67430.
10. Yu, Y., Y. Zhang, S. Hu, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Different patterns of cytokines and chemokines combined with IFN-gamma production reflect Mycobacterium tuberculosis infection and disease." PLoS One 7(9): e44944.
11. Qiu, Z., M. Zhang, Y. Zhu, F. Zheng, P. Lu, H. Liu, M. W. Graner, B. Zhou and X. Chen (2012). "Multifunctional CD4 T cell responses in patients with active tuberculosis." Sci Rep 2: 216.
12. Liu, K., Y. Zhang, S. Hu, Y. Yu, Q. Yang, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis." PLoS One 7(6): e38429.
13. Zhang, M., Z. Wang, M. W. Graner, L. Yang, M. Liao, Q. Yang, J. Gou, Y. Zhu, C. Wu, H. Liu, B. Zhou and X. Chen (2011). "B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis." Cell Immunol 270(2): 217-223.
14. Bai, X., K. Chmura, A. R. Ovrutsky, R. P. Bowler, R. I. Scheinman, R. E. Oberley-Deegan, H. Liu, S. Shang, D. Ordway and E. D. Chan (2011). "Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription." Tuberculosis (Edinb) 91(1): 26-35.
15. Chen, X., M. Zhang, X. Zhu, Q. Deng, H. Liu, N. Larmonier, M. W. Graner and B. Zhou (2009). "Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy." J Infect Dis 200(3): 399-408.
16. Niedbala, W., B. Cai, H. Liu, N. Pitman, L. Chang, and F.Y. Liew, Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A, 2007. 104(39): p. 15478-83.
17. Liu, H. and B.P. Leung, CD4+CD25+ regulatory T cells in health and disease. Clin Exp Pharmacol Physiol, 2006. 33(5-6): p. 519-24.
18. Liu, H., M. Komai-Koma, D. Xu, and F.Y. Liew, Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A, 2006. 103(18): p. 7048-53.
19. Liew, F.Y., H. Liu, and D. Xu, A novel negative regulator for IL-1 receptor and Toll-like receptor 4. Immunol Lett, 2005. 96(1): p. 27-31.
20. Xu, D., H. Liu, and M. Komai-Koma, Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol, 2004. 1(4): p. 239-46.
21. Brint, E.K., D. Xu, H. Liu, A. Dunne, A.N. McKenzie, L.A. O'Neill, and F.Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol, 2004. 5(4): p. 373-9
22. Xu, D., H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew, CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol, 2003. 170(1): p. 394-9.
23. Liu, H., B. Hu, D. Xu, and F.Y. Liew, CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol, 2003. 171(10): p. 5012-7.
研究生培養
培養博士研究生4名，碩士研究生4名，3名碩士研究生在讀。